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تم مناقشة اطروحة طالب الدكتوراه (فراس فارس رجا) اختصاص علوم الحياة / فسلجة حيوان يوم الخميس الموافق 18 / 4 / 2019 وعلى قاعة كلية العلوم للمناقشات - جامعة تكريت، عن رسالته الموسومة (مقارنة فسلجية وكيموحيوية لمنظمات الكالسيوم بين بعض امراض العظام و مرض الكلى المزمن) وقد تألفت لجنة المناقشة من: 

أ.  د. صاحب جمعة عبد الرحمن                                                                (رئيساً)

أ. د. رفاه رزوق حميد                                                                             (عضواً)

أ. م. د. عصمت جمال جميل                                                                     (عضواً)

أ. م. د. جواد علي صالح                                                                          (عضواً)

 أ. م. د. سوزان جميل علي                                                                       (عضواً)

 أ. د. زيد محمد مبارك                                                                             (عضواً ومشرفاً)

 أ. م. د. سرى زاحم حسين                                                                        (عضواً ومشرفاً)

وقد تضمنت الرسالة: 

 Cross sectional study was carried out to investigated the physiological and biochemical comparative between calcium regulators at some bone and chronic kidney disease, conducted in Dijla for Medical Rehabilitation Hospital, Salah Alden General Hospital and Dialysis Unit in Tikrit Teaching Hospital in Tikrit city. The study started from January 2018 to August 2018 on study population age ranged from (18 – 68) years old. The total of subjects were 150 individuals, 30 (15 males and 15 females) individuals assigned as control group and 120 patients which divided into two main groups: bone diseases (60 patients) which divided into subgroups: Osteoporosis and Osteomalacia (10 males and 20 females) for each group; and Chronic Kidney Disease (60 patients ) which divided into CKD with hemodialysis and CKD without hemodialysis (15 males and 15 females) for each group.Enzyme Linked Immunosorbent Assay (ELISA) kits were used to evaluate levels of serum Osteoprotegren (OPG) , Transforming growth factor - β (TGF – β) , Sclerostin ( SOST ) ,Osteocalcin (OC) , Calcium sensing receptor (CaSR), parathyroid hormone (PTH) , vitamin D (Vit.D), Calcitonin (CT) , and C-reactive protein (CRP); Whereas used spectrophotometer to detect calcium (Ca) , phosphorus (PO4) , magnesium (Mg) , alkaline phosphatase (ALP), albumin ,uric acid (UA) , Ionized Calcium (iCa) and corrected calcium. In osteoporosis patients there were significant increased (P≤0.05) in the levels of OPG and UA; whereas no significant increased (P≥0.05) for levels SOST, OC, PTH and ALP when compared with control. On other hand there was highly significant decrease (P≤0.01) in the levels of Ca, CRP, iCa and Corrected Ca., but no significant decrease (P≥0.05) in the levels of TGF-β, CaSR, vit D , Mg, whereas PO4 and albumin were significant decreased (P≤0.05) when compared with control. In Osteomalacia patients there were highly significant increased (P≤0.01) in the levels of OPG, CT, CRP and UA, while no significantincreased (P≥0.05) in levels of SOST, Mg and ALP, but significant increased (P≤0.05) in the levels of OC when compared with control. Contrarily the results showed highly significant decrease (P≤0.01) in the levels of CaSR, Vit. D, Ca, iCa and Corrected Ca., but no significant decreased (P≥0.05) in the levels of PTH and Albumin ; whereas significant decrease (P≤0.05) in levels TGF-β and PO4 when compared with control. The level of OPG, TGF- β, SOST, OC, CaSR, PTH, Vit. D, CT, CRP, ALP, PO4 and UA were highly significant increased (P≤0.01) atCKD with HD patients when compared with control; whereas the Ca, Corrected Ca, iCa and albumin where highly significant decreased (P≤0.01) in this group of CDK. The study showed there was a highly significant increased (P≤0.01) in the levels of OPG, SOST, CT, PO4, CRP, ALP and UA; whereas OC and Mg appears increased with no significantly difference (P≥0.05) at CKD without HD when compared with control, while TGF-β and Corrected Ca. were significant decreased (P≤0.05), but no significant decreased (P≥0.05) with vit D, whereas highly significant decreased (P≤0.01) with CaSR , iCa and albumin when compared with control. The present study showed there was a positive correlation between CaSR and (OPG, TGF-β, SOST, PTH, Calcitonin, Mg, ALP, Alb) but there was a negative correlation with(OT,Vit.D, Ca, PO4, CRP, UA, corr.ca, ica) at osteoporosis group , while at ostomalacia group the results appear a positive correlation between CaSR and (OPG, TGF-β, SOST, OT, Vit.D, PTH, Calcitonin, UA, Alb) but there was a negative correlation with (Ca, PO4, Mg, CRP, ALP, corr.ca, and ica) . Also , there was a positive correlation between CaSR and (OPG, TGF, SOST, OT, Vit.D, PTH, Calcitonin, Mg, CRP, ALP, UA, Alb) but there was a negative correlation with(Ca, PO4, corr.ca, ica) at CKD without HD group , while a positive correlation between CaSR and (OPG, TGF-β, SOST, OT, Vit.D, PTH, Calcitonin, Ca, Mg, ALP, corr.ca) but there was a negative correlation with(PO4, CRP, UA, Alb, and ica) at CKD with HD group. The current study showed that the calcium regulators more disturbance at CKD patients especially at CKD with HD than bone diseases.

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